Telomere capping

Across TCGA patient cohorts, RNA activity of the Telomere capping pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TERF2_S365, CMTR1, and POGZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere capping activity versus TERF2_S365 in PDAC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TERF2_S365 →	+0.463	+0.031	.001	.001	3	6
HNSC	CMTR1 →	+0.262	+0.075	<.001	<.001	3	5
HNSC	POGZ →	+0.268	+0.060	<.001	.001	2	6
BRCA	RFC2 →	+0.245	+0.021	.001	.002	3	5
UCEC	SMC1A →	+0.227	+0.056	<.001	.001	3	5
BRCA	SMC3 →	+0.217	+0.019	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016233 vs TERF2_S365 — PDAC

Explore this scatter interactively →