Synaptic vesicle coating

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle coating pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP3S2, AP3M2, and MRPS11, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle coating activity versus AP3S2 in CHOL (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	AP3S2 →	+0.715	+0.081	<.001	<.001	1	29
TGCT	AP3M2 →	+0.941	+0.075	<.001	<.001	3	26
TGCT	MRPS11 →	+0.496	+0.053	<.001	<.001	3	23
LAML	LETMD1 →	+0.465	+0.047	<.001	<.001	3	23
TGCT	SENP8 →	+0.790	+0.071	<.001	<.001	3	21
PCPG	RCCD1 →	+0.577	+0.037	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016183 vs AP3S2 — CHOL

Explore this scatter interactively →