Synaptic vesicle coating

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle coating pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN1B, FN3K, and ABCA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle coating activity versus SCN1B in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SCN1B →	+0.592	+0.588	.003	.007	3	4
GBM	FN3K →	+0.530	+0.107	.008	.005	3	4
BRCA	ABCA5 →	+0.685	+0.231	.001	.001	3	3
HNSC	PCAT7 →	+0.933	+0.683	<.001	.001	3	3
BRCA	AP3B2 →	+0.860	+0.224	<.001	<.001	3	3
GBM	DNAJC6 →	+0.746	+0.144	.007	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016183 vs SCN1B — HNSC

Explore this scatter interactively →