Synaptic vesicle coating

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle coating pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC1, FOSL1, and BNIP3L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMC1 grouped by Synaptic vesicle coating-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LAMC1 →	-1.449	-1.601	.002	<.001	3	4
SOFT_TISSUE	FOSL1 →	-3.418	-1.146	.002	.007	3	4
BREAST	BNIP3L →	-1.124	-0.681	.003	.006	3	4
BREAST	PLIN3 →	-1.030	-0.975	.008	.001	3	4
SKIN	FRMD6 →	-1.500	-1.259	<.001	<.001	3	4
CNS	VPS26A →	-0.537	-1.014	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMC1 by Synaptic vesicle coating activity — SOFT_TISSUE

Explore this box plot interactively →