Glycoside metabolic process

Across TCGA patient cohorts, RNA activity of the Glycoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1B10, TXNRD1, and AKR1C2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoside metabolic process activity versus AKR1B10 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1B10 →	+2.182	+0.103	<.001	<.001	3	6
LUAD	TXNRD1 →	+0.859	+0.104	<.001	<.001	3	5
LSCC	AKR1C2 →	+1.629	+0.144	<.001	<.001	3	5
LSCC	AKR1C3 →	+1.577	+0.147	<.001	<.001	3	5
UCEC	RAB22A →	-0.255	-0.082	.009	.007	3	5
LSCC	UGDH →	+0.598	+0.094	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016137 vs AKR1B10 — UCEC

Explore this scatter interactively →