Glycoside metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Glycoside metabolic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 20 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Glycoside metabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and BLCA, show the opposite pattern, with higher activity associated with better survival.

BRCA, BLCA, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.979	0.948	<.001	54	view →
BLCA	OS	Median	II,III,IV	0.765	0.651	.003	47	view →
DLBC	DFS	Tertile	IV	0.128	0.860	.003	33	view →
SKCM	OS	Tertile	All	0.891	0.702	<.001	32	view →
LGG	DFS	Quartile	All	0.244	0.457	<.001	29	view →
CESC	DFS	Median	All	0.820	0.668	.001	22	view →
LIHC	DFS	Tertile	II,III,IV	0.446	0.224	.010	17	view →
PAAD	DFS	Tertile	II,III,IV	0.318	0.531	.009	12	view →
MESO	OS	Quartile	All	0.699	0.491	.019	10	view →
LUSC	OS	Tertile	All	0.837	0.750	.023	10	view →
LUAD	DFS	Tertile	IV	0.559	1.000	.042	8	view →
COAD	OS	Median	III,IV	0.754	0.391	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0016137–BRCA (OS)

Open the BRCA breakdown →