Glycoside metabolic process

Across TCGA cell cohorts, RNA activity of the Glycoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP10, CASP1, and BIRC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THAP10 grouped by Glycoside metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	THAP10 →	-0.898	-1.068	.004	.002	3	4
LARGE_INTESTINE	CASP1 →	+1.686	+1.011	.004	.002	3	4
LARGE_INTESTINE	BIRC3 →	+1.353	+1.055	.001	<.001	3	4
URINARY_TRACT	CCDC74B →	+2.425	+1.842	.002	<.001	3	3
LUNG_NSCLC_LUSC	EDN1 →	-2.206	-1.147	.009	.003	3	3
LUNG_NSCLC_LUSC	PMEL →	+0.687	+1.247	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THAP10 by Glycoside metabolic process activity — LUNG_SCLC

Explore this box plot interactively →