Glycoside metabolic process

Across TCGA cell cohorts, RNA activity of the Glycoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, UGDH, and AKR1A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoside metabolic process activity versus GSR in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GSR →	+1.354	+0.866	.001	.003	3	8
KIDNEY	UGDH →	+2.033	+0.361	.002	.004	3	6
STOMACH	AKR1A1 →	+1.123	+1.407	.004	.006	2	7
UPPER_AERODIGESTIVE_TRACT	HNRNPA3 →	+1.027	+1.818	.003	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SH3BGR →	+1.051	+1.859	<.001	<.001	3	6
BLOOD_Leukemia	SGSM3 →	+0.864	+0.467	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016137 vs GSR — LUNG_NSCLC_LUAD

Explore this scatter interactively →