Sterol metabolic process

Across TCGA patient cohorts, RNA activity of the Sterol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IQGAP2_S16, PAICS_S27, and SPTBN1_S257, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol metabolic process activity versus IQGAP2_S16 in OV (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IQGAP2_S16 →	+0.821	+0.026	.001	.004	3	8
LUAD	PAICS_S27 →	-0.990	-0.029	<.001	<.001	3	7
LUAD	SPTBN1_S257 →	+0.732	+0.034	<.001	<.001	3	6
OV	SRRM2_S1132 →	-0.753	-0.027	.004	.006	3	6
PDAC	UTP4 →	-0.341	-0.028	<.001	<.001	3	6
BRCA	CDYL_S216 →	-0.664	-0.030	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016125 vs IQGAP2_S16 — OV

Explore this scatter interactively →