Sterol metabolic process

Across TCGA cell cohorts, RNA activity of the Sterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCYT2, FDFT1, and FDPS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol metabolic process activity versus PCYT2 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PCYT2 →	+1.286	+0.269	<.001	<.001	3	8
STOMACH	FDFT1 →	+1.438	+0.446	.003	<.001	3	7
BREAST	FDPS →	+0.736	+0.247	.008	.001	3	6
STOMACH	MVD →	+1.419	+0.308	<.001	<.001	3	6
STOMACH	IDI1 →	+1.649	+0.333	.001	.002	3	6
URINARY_TRACT	DHCR24 →	+1.690	+0.428	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016125 vs PCYT2 — BLOOD_Lymphoma

Explore this scatter interactively →