tRNA decay

Across TCGA patient cohorts, RNA activity of the tRNA decay pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FEZ1, SEPTIN4, and FILIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA decay activity versus FEZ1 in GBM (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FEZ1 →	-0.518	-0.153	.009	.001	3	7
GBM	SEPTIN4 →	-0.948	-0.147	.003	.002	3	7
UCEC	FILIP1 →	-0.590	-0.087	<.001	.009	3	6
OV	CNRIP1 →	-0.929	-0.267	<.001	.002	3	6
GBM	PLCL1 →	-0.952	-0.137	.003	.003	3	6
CCRCC	PEG3 →	-0.396	-0.221	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016078 vs FEZ1 — GBM

Explore this scatter interactively →