rRNA catabolic process

Across TCGA patient cohorts, RNA activity of the rRNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP9_S79, WDR11, and STIM2_S727, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA catabolic process activity versus MAP9_S79 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP9_S79 →	+0.522	+0.046	<.001	.005	3	5
COAD	WDR11 →	-0.143	-0.029	.007	<.001	3	4
HNSC	STIM2_S727 →	-0.444	-0.081	.003	.006	3	4
HNSC	EEF2_S502 →	-0.797	-0.089	<.001	<.001	3	4
PDAC	PHF3_S283 →	+0.333	+0.038	.003	.002	3	4
CCRCC	SND1_S645 →	-1.022	-0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016075 vs MAP9_S79 — LSCC

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