rRNA catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the rRNA catabolic process pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher rRNA catabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and SKCM, show the opposite pattern, with higher activity associated with better survival.

UVM, KICH, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.284	0.739	<.001	95	view →
KICH	DFS	Quartile	All	0.500	1.000	.001	76	view →
ACC	DFS	Median	All	0.427	0.722	<.001	72	view →
READ	OS	Median	II,III,IV	0.864	0.461	.001	62	view →
LUSC	OS	Tertile	III,IV	0.530	0.781	<.001	28	view →
KIRP	DFS	Quartile	All	0.503	0.849	<.001	25	view →
UCEC	OS	Tertile	All	0.891	0.951	.017	22	view →
KIRC	DFS	Median	II,III,IV	0.433	0.622	.007	16	view →
SKCM	OS	Tertile	IV	0.787	0.192	.007	15	view →
CHOL	DFS	Median	All	0.634	0.144	.021	12	view →
PRAD	OS	Tertile	All	0.975	1.000	.029	6	view →
COAD	DFS	Tertile	IV	0.639	0.382	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0016075–UVM (DFS)

Open the UVM breakdown →