rRNA catabolic process

Across TCGA cell cohorts, RNA activity of the rRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF4B, NOB1, and RPL15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA catabolic process activity versus TAF4B in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TAF4B →	+1.258	+0.801	.008	.009	3	7
SKIN	NOB1 →	+0.801	+1.757	<.001	<.001	3	6
BREAST	RPL15 →	+0.730	+1.573	.003	<.001	3	6
PANCREAS	TRNT1 →	+1.040	+1.908	.006	.002	3	6
LARGE_INTESTINE	POLR3G →	+1.284	+0.965	.002	.005	3	6
LARGE_INTESTINE	HSPD1 →	+0.858	+1.079	.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016075 vs TAF4B — LUNG_SCLC

Explore this scatter interactively →