Detection of temperature stimulus

Across TCGA cell cohorts, RNA activity of the Detection of temperature stimulus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF404, TRIM59, and SP110, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF404 grouped by Detection of temperature stimulus-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF404 →	-0.836	-0.478	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TRIM59 →	+1.209	+0.223	.004	.002	3	4
BLOOD_Myeloma	SP110 →	-1.190	-0.372	.007	.004	3	3
BLOOD_Myeloma	TRPM2 →	+2.115	+0.263	.003	.005	3	3
BLOOD_Myeloma	C1QTNF12 →	+1.359	+0.409	.002	.001	3	3
BLOOD_Myeloma	INCA1 →	-0.438	-0.369	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF404 by Detection of temperature stimulus activity — URINARY_TRACT

Explore this box plot interactively →