CDP-diacylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the CDP-diacylglycerol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GMPPA, NUBP1, and SEC23B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CDP-diacylglycerol biosynthetic process activity versus GMPPA in UCEC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GMPPA →	-0.220	-0.043	.002	.009	3	4
BRCA	NUBP1 →	-0.330	-0.035	<.001	<.001	3	4
LSCC	SEC23B →	-0.232	-0.039	<.001	.002	3	4
LSCC	ATP2A2_S663 →	-0.448	-0.039	<.001	.005	3	4
LSCC	GMPPB →	-0.262	-0.035	.002	.006	3	4
OV	GSDMD →	-0.313	-0.032	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016024 vs GMPPA — UCEC

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