CDP-diacylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the CDP-diacylglycerol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDS1, TMEM167B, and CDS1_S9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CDP-diacylglycerol biosynthetic process activity versus CDS1 in BRCA (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDS1 →	+0.814	+0.446	.003	.006	2	8
PDAC	TMEM167B →	+0.671	+0.355	<.001	<.001	3	5
UCEC	CDS1_S9 →	+1.207	+0.240	<.001	<.001	3	5
UCEC	LETM1 →	+0.442	+0.222	<.001	<.001	3	5
PDAC	ALG3_S13 →	+1.003	+0.452	<.001	<.001	3	5
BRCA	ATP5MPL →	+0.877	+0.550	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016024 vs CDS1 — BRCA

Explore this scatter interactively →