CDP-diacylglycerol biosynthetic process

Across TCGA cell cohorts, RNA activity of the CDP-diacylglycerol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSPH, C10orf88, and LONP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CDP-diacylglycerol biosynthetic process activity versus PSPH in BLOOD_Lymphoma (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PSPH →	-1.057	-1.068	.006	.002	3	4
SOFT_TISSUE	C10orf88 →	+0.390	+0.528	<.001	.007	3	3
SKIN	LONP1 →	-0.949	-1.009	<.001	.006	3	3
BLOOD_Myeloma	SIRT3 →	-0.962	-0.381	.007	.006	3	3
CNS	PLIN1 →	+0.141	+0.679	.002	.004	3	3
BLOOD_Lymphoma	GRK3 →	-1.435	-0.850	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016024 vs PSPH — BLOOD_Lymphoma

Explore this scatter interactively →