Nucleobase-containing small molecule interconversion

Across TCGA patient cohorts, RNA activity of the Nucleobase-containing small molecule interconversion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL10A1, AK4, and HOPX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule interconversion activity versus COL10A1 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL10A1 →	+1.185	+0.078	.004	.009	3	4
LUAD	AK4 →	+0.927	+0.122	<.001	<.001	3	4
BRCA	HOPX →	+0.716	+0.133	<.001	<.001	3	4
LSCC	MIR210HG →	+0.592	+0.107	.003	.003	3	4
COAD	KCTD21 →	+0.294	+0.142	.001	<.001	3	4
UCEC	RNU7-63P →	-1.068	-0.087	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015949 vs COL10A1 — BRCA

Explore this scatter interactively →