Coenzyme A biosynthetic process

Across TCGA patient cohorts, RNA activity of the Coenzyme A biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARS2, RGS3_S1007, and SEPTIN4_S117, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coenzyme A biosynthetic process activity versus CARS2 in OV (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CARS2 →	-0.488	-0.036	.003	.004	3	5
LSCC	RGS3_S1007 →	+0.513	+0.032	<.001	<.001	3	5
LSCC	SEPTIN4_S117 →	+0.427	+0.028	.002	.001	3	5
LSCC	PECAM1 →	+0.365	+0.044	<.001	<.001	3	5
HNSC	RERE_S656 →	+0.363	+0.081	<.001	<.001	3	4
HNSC	ROGDI →	+0.203	+0.054	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015937 vs CARS2 — OV

Explore this scatter interactively →