Coenzyme A biosynthetic process

Across TCGA cell cohorts, RNA activity of the Coenzyme A biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCL, CLTA, and SEMA4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYCL grouped by Coenzyme A biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYCL →	-1.244	-1.155	.001	<.001	2	4
URINARY_TRACT	CLTA →	+0.901	+1.575	.002	.003	3	3
URINARY_TRACT	SEMA4A →	-3.459	-2.224	.003	<.001	3	3
PANCREAS	OPA1 →	+0.759	+0.380	<.001	<.001	3	3
LARGE_INTESTINE	CEL →	-1.932	-1.172	.007	<.001	3	3
KIDNEY	DDB2 →	-1.519	-1.662	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYCL by Coenzyme A biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →