Coenzyme A biosynthetic process

Across TCGA cell cohorts, RNA activity of the Coenzyme A biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT7, MYO5B, and IKZF2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coenzyme A biosynthetic process activity versus ACOT7 in LUNG_SCLC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACOT7 →	+1.215	+0.280	<.001	<.001	3	9
LUNG_NSCLC_LUAD	MYO5B →	-1.352	-0.238	.007	.001	2	7
URINARY_TRACT	IKZF2 →	-2.695	-0.281	.003	.007	3	6
LUNG_NSCLC_LUAD	TMPRSS13 →	-2.496	-0.281	<.001	<.001	3	5
LUNG_NSCLC_LUAD	FAM216A →	+1.121	+0.305	.001	.006	3	5
OESOPHAGUS	ATP1A3 →	+1.912	+0.495	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015937 vs ACOT7 — LUNG_SCLC

Explore this scatter interactively →