Coenzyme A metabolic process

Across TCGA patient cohorts, RNA activity of the Coenzyme A metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MED12_S2163, PICK1, and IGF2BP2_S162, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coenzyme A metabolic process activity versus MED12_S2163 in HNSC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MED12_S2163 →	-0.379	-0.076	<.001	.004	3	4
HNSC	PICK1 →	+0.499	+0.075	<.001	<.001	3	4
OV	IGF2BP2_S162 →	-0.885	-0.035	<.001	<.001	3	4
OV	IRF2BPL_S69 →	-0.718	-0.035	<.001	<.001	3	4
LSCC	CLUH →	+0.190	+0.029	.007	.005	3	4
CCRCC	RUNX1_S21 →	-0.326	-0.035	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015936 vs MED12_S2163 — HNSC

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