Coenzyme A metabolic process

Across TCGA patient cohorts, RNA activity of the Coenzyme A metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF280B, SEPTIN3, and SNRPFP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coenzyme A metabolic process activity versus ZNF280B in CCRCC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF280B →	-0.581	-0.202	.001	.002	3	4
GBM	SEPTIN3 →	-1.232	-0.169	<.001	.004	3	3
BRCA	SNRPFP4 →	-0.367	-0.154	<.001	<.001	3	3
PDAC	C17orf64 →	-0.084	-0.157	<.001	<.001	3	3
HNSC	FGFR4 →	-0.519	-0.098	.002	.007	3	3
GBM	SRRD →	-0.273	-0.132	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015936 vs ZNF280B — CCRCC

Explore this scatter interactively →