Coenzyme A metabolic process

Across TCGA cell cohorts, RNA activity of the Coenzyme A metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAP3, FSTL1, and LHFPL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DAP3 grouped by Coenzyme A metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DAP3 →	+0.722	+0.739	<.001	.004	3	4
BREAST	FSTL1 →	-2.589	-0.683	.006	.002	3	4
BREAST	LHFPL6 →	-2.497	-0.930	<.001	<.001	3	4
BLOOD_Myeloma	SMG5 →	+0.814	+0.314	.003	.004	3	4
STOMACH	SLC51A →	-0.743	-1.226	.005	.003	3	4
BLOOD_Myeloma	ZNF726 →	-2.520	-0.409	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DAP3 by Coenzyme A metabolic process activity — BREAST

Explore this box plot interactively →