Coenzyme A metabolic process

Across TCGA cell cohorts, RNA activity of the Coenzyme A metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT7, DUSP3, and RPGR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coenzyme A metabolic process activity versus ACOT7 in SOFT_TISSUE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACOT7 →	+0.997	+0.478	.006	.002	3	6
BLOOD_Lymphoma	DUSP3 →	+1.590	+0.265	.002	<.001	3	5
KIDNEY	RPGR →	+0.874	+0.195	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ABCA2 →	+2.022	+0.239	.008	.008	3	5
URINARY_TRACT	TANGO6 →	+0.793	+0.339	<.001	<.001	3	5
URINARY_TRACT	CFAP36 →	+1.520	+0.390	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015936 vs ACOT7 — SOFT_TISSUE

Explore this scatter interactively →