Nucleobase-containing compound transport

Across TCGA patient cohorts, RNA activity of the Nucleobase-containing compound transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, TPR, and ADNP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing compound transport activity versus SMC1A in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMC1A →	+0.244	+0.058	<.001	.002	3	5
HNSC	TPR →	+0.121	+0.047	<.001	.003	3	5
HNSC	ADNP →	+0.238	+0.053	<.001	<.001	3	5
LUAD	CMTR1 →	+0.310	+0.031	<.001	<.001	3	5
HNSC	FLNB →	-0.474	-0.067	<.001	<.001	3	5
HNSC	HCFC1 →	+0.190	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015931 vs SMC1A — HNSC

Explore this scatter interactively →