Phospholipid transport

Across TCGA patient cohorts, RNA activity of the Phospholipid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF8, RFC1, and KIF23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid transport activity versus PRPF8 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF8 →	-0.226	-0.033	<.001	<.001	3	6
LSCC	RFC1 →	-0.297	-0.032	<.001	<.001	3	6
LSCC	KIF23 →	-0.545	-0.046	<.001	<.001	3	6
BRCA	LPXN →	+0.427	+0.021	.002	.001	3	6
LSCC	PICALM →	+0.288	+0.039	<.001	<.001	3	6
GBM	PIK3R1 →	+0.243	+0.036	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015914 vs PRPF8 — GBM

Explore this scatter interactively →