Phospholipid transport

Across TCGA pan-cancer cohorts, RNA activity of the Phospholipid transport pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LIHC and KIRP, show the opposite pattern, with lower activity in tumor tissue.

LIHC, KIRP, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	Female	II,III,IV	−0.043	<.001	9	view →
KIRP	Male	II,III,IV	−0.025	<.001	8	view →
LUSC	Female	All	−0.044	<.001	6	view →
BRCA	All	III,IV	−0.022	<.001	6	view →
CHOL	All	All	−0.082	<.001	5	view →
COAD	Female	All	−0.022	<.001	4	view →
LUAD	All	All	−0.012	.004	3	view →
UCEC	All	IV	+0.034	.019	2	view →
THCA	Female	III,IV	+0.020	.049	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0015914–LIHC

Open the LIHC breakdown →