Phospholipid transport

Across TCGA patient cohorts, RNA activity of the Phospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUCKS1, POLA1, and PLEKHA4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid transport activity versus NUCKS1 in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUCKS1 →	-0.359	-0.211	.007	.002	3	5
UCEC	POLA1 →	-0.320	-0.177	.002	.004	3	4
UCEC	PLEKHA4 →	-0.650	-0.204	<.001	.001	3	4
UCEC	RIC8B →	-0.251	-0.171	.001	.006	3	4
UCEC	CASP8AP2 →	-0.233	-0.183	.008	.003	3	4
BRCA	DHX57 →	-0.388	-0.218	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015914 vs NUCKS1 — UCEC

Explore this scatter interactively →