Phospholipid transport

Across TCGA cell cohorts, RNA activity of the Phospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCN2, SERPINB6, and NPC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCN2 grouped by Phospholipid transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TCN2 →	-1.436	-1.013	.001	<.001	3	6
BONE	SERPINB6 →	-2.996	-1.482	.002	.003	3	6
OESOPHAGUS	NPC2 →	-0.943	-0.814	.009	.008	2	6
SOFT_TISSUE	NASP →	+0.693	+1.298	.008	.004	3	5
PANCREAS	HYPK →	+0.936	+1.240	.001	<.001	3	5
CNS	TPST1 →	-1.110	-0.932	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCN2 by Phospholipid transport activity — OESOPHAGUS

Explore this box plot interactively →