Phospholipid transport

Across TCGA cell cohorts, RNA activity of the Phospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP1, RPL10A, and SDC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid transport activity versus LAMP1 in CNS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LAMP1 →	+0.707	+0.151	.002	.002	3	8
OVARY	RPL10A →	-0.891	-0.275	.004	<.001	3	7
LUNG_SCLC	SDC4 →	+2.732	+0.212	.001	.005	3	6
LUNG_SCLC	RPL4 →	-0.943	-0.217	<.001	<.001	3	6
LARGE_INTESTINE	RPL3 →	-0.569	-0.190	.008	.004	2	7
OVARY	RPL18A →	-0.852	-0.184	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015914 vs LAMP1 — CNS

Explore this scatter interactively →