Long-chain fatty acid transport

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAV1, CAV1_S37, and PLIN4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid transport activity versus CAV1 in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAV1 →	+0.865	+0.060	<.001	<.001	3	7
OV	CAV1_S37 →	+0.738	+0.028	.001	.007	3	7
OV	PLIN4 →	+1.273	+0.032	<.001	<.001	3	6
GBM	CAVIN1 →	+0.818	+0.070	<.001	<.001	3	6
GBM	CAVIN3 →	+0.703	+0.075	<.001	<.001	3	6
OV	CD36 →	+1.341	+0.034	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015909 vs CAV1 — GBM

Explore this scatter interactively →