Long-chain fatty acid transport

Across TCGA cell cohorts, RNA activity of the Long-chain fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAG1, RNF144B, and TMOD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid transport activity versus JAG1 in OVARY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	JAG1 →	+2.330	+0.224	.006	.004	3	5
OVARY	RNF144B →	+1.812	+0.187	.004	.001	3	5
LUNG_SCLC	TMOD2 →	-1.351	-0.863	.001	.004	3	5
LUNG_SCLC	RHBDL3 →	-2.415	-1.282	<.001	<.001	3	5
BLOOD_Myeloma	USP13 →	-0.783	-0.214	<.001	.005	2	5
SKIN	CEP19 →	-0.670	-0.201	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015909 vs JAG1 — OVARY

Explore this scatter interactively →