Cobalamin transport

Across TCGA patient cohorts, RNA activity of the Cobalamin transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SKP266, LYRM1, and EARS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin transport activity versus RN7SKP266 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SKP266 →	-0.661	-0.671	.002	.001	3	4
BRCA	LYRM1 →	+0.463	+0.544	.002	.001	3	3
BRCA	EARS2 →	+0.522	+0.540	.001	.006	3	3
BRCA	RAB11A →	+0.408	+0.528	.002	.001	3	3
BRCA	HPN →	+1.639	+0.720	<.001	<.001	3	3
BRCA	CFAP69 →	+0.793	+0.702	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015889 vs RN7SKP266 — GBM

Explore this scatter interactively →