Folic acid transport

Across TCGA cell cohorts, RNA activity of the Folic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC11, PAPOLA, and ERLIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC11 grouped by Folic acid transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNAJC11 →	+0.763	+1.274	<.001	<.001	3	4
STOMACH	PAPOLA →	+0.731	+1.007	.001	.004	3	4
BLOOD_Myeloma	ERLIN2 →	+1.212	+1.479	.003	.007	3	4
PANCREAS	KCNC3 →	-0.888	-1.697	.001	<.001	3	3
PANCREAS	CCDC90B →	+0.729	+1.227	.003	.006	3	3
PANCREAS	STAC3 →	-0.475	-0.960	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC11 by Folic acid transport activity — SKIN

Explore this box plot interactively →