Norepinephrine transport

Across TCGA cell cohorts, RNA activity of the Norepinephrine transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRED1, MAN1A1, and DENND2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPRED1 grouped by Norepinephrine transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPRED1 →	-1.561	-1.292	<.001	.002	3	4
STOMACH	MAN1A1 →	-3.275	-1.646	.001	<.001	3	4
BONE	DENND2C →	+2.684	+1.326	.007	.007	3	4
PANCREAS	WNT10A →	+2.188	+1.114	.005	.007	3	4
LUNG_NSCLC_LUSC	MRPL42 →	-0.854	-1.411	.001	.002	3	3
LUNG_NSCLC_LUSC	GCN1 →	-0.706	-1.670	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPRED1 by Norepinephrine transport activity — SOFT_TISSUE

Explore this box plot interactively →