Choline transport

Across TCGA patient cohorts, RNA activity of the Choline transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, REPS2_T479, and UTP15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Choline transport activity versus SMC4 in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	-0.526	-0.095	.004	<.001	3	7
LUAD	REPS2_T479 →	+0.398	+0.074	.001	.003	3	6
UCEC	UTP15 →	-0.245	-0.134	.001	<.001	3	6
LUAD	DDAH1 →	+0.510	+0.074	<.001	<.001	3	6
GBM	NCAPD2 →	-0.500	-0.079	<.001	<.001	3	6
BRCA	NCAPH →	-0.561	-0.054	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015871 vs SMC4 — GBM

Explore this scatter interactively →