ADP transport

Across TCGA patient cohorts, RNA activity of the ADP transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, GATB, and FAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP transport activity versus SLC25A4 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC25A4 →	+0.527	+0.138	.001	<.001	3	4
CCRCC	GATB →	+0.304	+0.141	.002	.004	3	4
LSCC	FAP →	-0.563	-0.059	.001	.003	3	4
PDAC	STK16 →	+0.169	+0.145	.004	.004	3	4
LUAD	ESRG →	+0.035	+0.057	.008	.005	3	3
CCRCC	CDC42P2 →	-1.253	-0.142	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015866 vs SLC25A4 — BRCA

Explore this scatter interactively →