Purine nucleotide transport

Across TCGA patient cohorts, RNA activity of the Purine nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA2D1, MXRA5, and PC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleotide transport activity versus CACNA2D1 in LUAD (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CACNA2D1 →	-0.507	-0.434	.006	.007	3	4
GBM	MXRA5 →	-0.950	-0.226	.007	.001	3	3
GBM	PC →	+0.318	+0.191	.003	<.001	3	3
GBM	HMGN1P33 →	+0.136	+0.244	<.001	<.001	3	3
HNSC	MYOM1 →	-1.124	-0.222	<.001	<.001	3	3
HNSC	RNF125 →	-0.576	-0.227	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015865 vs CACNA2D1 — LUAD

Explore this scatter interactively →