Nucleoside transport

Across TCGA patient cohorts, RNA activity of the Nucleoside transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEMA4D, DIMT1, and PPFIBP1_S37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside transport activity versus SEMA4D in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEMA4D →	+0.258	+0.070	.002	.002	3	4
LSCC	DIMT1 →	+0.228	+0.053	<.001	<.001	3	4
LSCC	PPFIBP1_S37 →	-0.237	-0.060	.009	.003	3	4
LSCC	ARHGEF40_S961 →	+0.541	+0.091	.006	.002	2	5
PDAC	SPARC →	-0.338	-0.078	.009	<.001	3	4
COAD	CRTAP →	-0.408	-0.063	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015858 vs SEMA4D — LSCC

Explore this scatter interactively →