Adenine transport

Across TCGA patient cohorts, RNA activity of the Adenine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOWAHC, KRT5_T24, and PLEKHA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenine transport activity versus SOWAHC in LSCC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOWAHC →	-0.332	-0.060	<.001	.003	3	5
LSCC	KRT5_T24 →	-0.878	-0.051	<.001	<.001	3	5
LSCC	PLEKHA6 →	+0.694	+0.088	<.001	<.001	3	5
LSCC	PRNP →	-0.422	-0.064	.004	<.001	3	5
HNSC	TCEA3_S115 →	+0.735	+0.097	<.001	<.001	3	5
PDAC	ATP1B1 →	+0.498	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015853 vs SOWAHC — LSCC

Explore this scatter interactively →