Nucleobase transport

Across TCGA patient cohorts, RNA activity of the Nucleobase transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FCN1, CAMP, and ICAM1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase transport activity versus FCN1 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCN1 →	+0.924	+0.072	<.001	<.001	3	9
GBM	CAMP →	+1.409	+0.083	<.001	<.001	3	8
GBM	ICAM1 →	+0.580	+0.065	<.001	<.001	3	8
GBM	ITGAM →	+0.652	+0.087	<.001	<.001	3	8
BRCA	ITGB2 →	+0.554	+0.056	<.001	<.001	3	8
BRCA	NCF1 →	+0.636	+0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015851 vs FCN1 — GBM

Explore this scatter interactively →