Nucleobase transport

Across TCGA pan-cancer cohorts, RNA activity of the Nucleobase transport pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Nucleobase transport pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and ACC, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.546	0.279	<.001	92	view →
ACC	OS	Tertile	II,III,IV	0.738	0.337	<.001	80	view →
UCEC	DFS	Quartile	All	0.778	0.894	.001	42	view →
GBM	DFS	Median	All	0.171	0.388	<.001	30	view →
UVM	DFS	Median	III,IV	0.740	0.365	.002	29	view →
LUAD	OS	Median	III,IV	0.683	0.368	.002	22	view →
KIRP	DFS	Tertile	All	1.000	0.788	.016	16	view →
LUSC	OS	Median	All	0.623	0.718	.015	15	view →
LGG	DFS	Median	All	0.669	0.796	<.001	14	view →
KIRC	DFS	Quartile	III,IV	0.801	0.636	.014	13	view →
THYM	DFS	Median	All	0.968	0.772	.019	12	view →
STAD	OS	Quartile	IV	0.163	0.662	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0015851–MESO (OS)

Open the MESO breakdown →