Nucleobase transport

Across TCGA patient cohorts, RNA activity of the Nucleobase transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, KL, and RAC3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase transport activity versus SLC25A4 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC25A4 →	+0.739	+0.155	<.001	.005	3	3
COAD	KL →	+0.371	+0.090	<.001	.005	3	3
COAD	RAC3 →	-0.803	-0.102	.001	.007	3	3
COAD	CCDC106 →	+0.439	+0.107	<.001	<.001	3	3
COAD	CAB39P1 →	-0.320	-0.129	.002	.002	3	3
COAD	HMBS →	-0.493	-0.118	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015851 vs SLC25A4 — HNSC

Explore this scatter interactively →