Nucleobase transport

Across TCGA cell cohorts, RNA activity of the Nucleobase transport pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A5, SLC25A4, and WNT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A5 grouped by Nucleobase transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC25A5 →	-0.370	-0.867	<.001	.004	3	8
LUNG_SCLC	SLC25A4 →	-0.213	-1.328	.003	.003	2	7
BONE	WNT2 →	-0.166	-0.713	.001	.003	3	5
LUNG_NSCLC_LUAD	HRH3 →	-0.214	-0.674	.002	.005	3	5
LARGE_INTESTINE	NAALADL1 →	-0.211	-1.123	.004	.002	3	4
OESOPHAGUS	ZNF140 →	-0.181	-0.515	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A5 by Nucleobase transport activity — SKIN

Explore this box plot interactively →