Nucleobase transport

Across TCGA cell cohorts, RNA activity of the Nucleobase transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G15, ADGRE5, and S100A5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLA2G15 grouped by Nucleobase transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLA2G15 →	-1.480	-1.785	<.001	<.001	3	5
LUNG_NSCLC_LUSC	ADGRE5 →	-2.398	-0.944	<.001	.007	3	4
LUNG_NSCLC_LUSC	S100A5 →	-0.679	-1.021	<.001	.002	3	4
OESOPHAGUS	SHCBP1 →	-1.025	-0.327	.003	.009	3	4
KIDNEY	TRIM7 →	-1.155	-0.997	.007	.003	3	4
PANCREAS	ZNF700 →	-0.774	-1.068	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLA2G15 by Nucleobase transport activity — SOFT_TISSUE

Explore this box plot interactively →