Nucleobase transport

Across TCGA cell cohorts, RNA activity of the Nucleobase transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP4B, HGSNAT, and ZNF585B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase transport activity versus INPP4B in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	INPP4B →	+1.386	+0.237	<.001	<.001	3	5
BLOOD_Leukemia	HGSNAT →	+1.601	+0.229	<.001	.001	3	5
SOFT_TISSUE	ZNF585B →	+1.385	+0.147	.006	.009	3	5
LIVER	CHIC1 →	+1.615	+0.204	.001	<.001	3	4
LUNG_SCLC	IKBKB →	+1.250	+0.200	.003	.007	2	5
BLOOD_Leukemia	DENND3 →	+2.416	+0.203	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015851 vs INPP4B — BLOOD_Leukemia

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