Spermidine transport

Across TCGA patient cohorts, RNA activity of the Spermidine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, ST6GALNAC1_S393, and THBS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermidine transport activity versus SMC4 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC4 →	-0.378	-0.132	<.001	<.001	3	5
LUAD	ST6GALNAC1_S393 →	+0.588	+0.137	<.001	<.001	3	5
LUAD	THBS1 →	-0.824	-0.102	<.001	.003	3	5
LUAD	BRI3BP_S248 →	-1.831	-0.150	<.001	<.001	3	5
LSCC	CEBPZ_S629 →	-0.531	-0.123	<.001	.001	3	5
LUAD	GNG12_S49 →	+0.620	+0.142	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015848 vs SMC4 — LUAD

Explore this scatter interactively →