Monoamine transport

Across TCGA patient cohorts, RNA activity of the Monoamine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KHSRP, NXF1, and DMXL2_S1400, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoamine transport activity versus KHSRP in LSCC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KHSRP →	-0.245	-0.030	<.001	<.001	3	5
GBM	NXF1 →	-0.290	-0.064	.001	<.001	3	5
GBM	DMXL2_S1400 →	+0.396	+0.054	.004	<.001	3	5
LSCC	REV1_S1097 →	-0.798	-0.036	.001	<.001	3	4
LSCC	SERPINB1 →	+0.377	+0.026	.003	.001	3	4
GBM	ATN1_S645 →	-0.334	-0.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015844 vs KHSRP — LSCC

Explore this scatter interactively →